Pre-Conference Workshop: State-of-the-Art Technologies to Advance the Next Generation of FTD Researchers - Track A: “An Introduction to FTD” (Separate Registration Required)
8:00 AM - 8:25 AM
Progressive Supranuclear Palsy and Corticobasal Syndrome
Speaker:
James Rowe (UK)
Moderator:
Corey McMillan (USA)
8:25 AM - 8:50 AM
Primary Progressive Aphasia
Speaker:
Marsel Mesulam (USA)
Moderator:
Corey McMillan (USA)
8:50 AM - 9:15 AM
Behavioral Variant Frontotemporal Dementia
Speaker:
Olivier Piguet (University of Sydney)
Moderator:
Corey McMillan (USA)
9:15 AM - 9:40 AM
ALS-FTD
Speaker:
Michael Strong (Canada)
Moderator:
Corey McMillan (USA)
9:40 AM - 10:00 AM
Clinical Outcome Measures for FTD Trials
Speaker:
Howie Rosen (USA)
Moderator:
Corey McMillan (USA)
10:00 AM - 10:15 AM
Coffee Break
10:15 AM - 10:40 AM
Genetics of FTD
Speaker:
Vivianna Van Deerlin (USA)
Moderator:
David Irwin (USA)
10:40 AM - 11:05 AM
FTLD-TDP and FTLD-FET
Speaker:
Manuela Neumann (Germany)
Moderator:
David Irwin (USA)
11:05 AM - 11:30 AM
FTLD-Tau
Speaker:
Dennis Dickson (USA)
Moderator:
David Irwin (USA)
11:30 AM - 12:00 PM
Interactive Digital Pathology Session: Review of Digital Images of Exemplar FTLD Pathology with Audience Participation
Moderator:
David Irwin (USA)
8:00 AM - 12:00 PM
Salon K
Pre-Conference Workshop: State-of-the-Art Technologies to Advance the Next Generation of FTD Researchers - Track B: “Advanced Techniques in FTD Research” (Separate Registration Required)
8:00 AM - 8:25 AM
Spatial-Omics From Postmortem Tissue in ALS-FTD
Speaker:
Hemali Phatnani (USA)
Moderator:
David Irwin (USA)
8:25 AM - 8:50 AM
Cryo-EM Approaches to Study Protein Aggregates
Speaker:
Edward Lee (University of Pennsylvania)
Moderator:
David Irwin (USA)
8:50 AM - 9:15 AM
Open-Source Digital Pathology
Speaker:
Paul Yushkevich (USA)
Moderator:
David Irwin (USA)
9:15 AM - 10:00 AM
Hands-on Digital Pathology Session: Interactive Digital Pathology Demonstration of Image Thresholding, Segmentation and Object Detection
Speaker:
Daniel Ohm (University of Pennsylvania)
Moderator:
David Irwin (USA)
10:00 AM - 10:15 AM
Coffee Break
10:15 AM - 10:40 AM
Strategies for Identifying Prodromal Behavior & Cognition in Genetic FTD & ALS
Speaker:
Ted Huey (USA)
Moderator:
Corey McMillan (USA)
10:40 AM - 11:05 AM
Computational Analysis of Digital Speech Samples in PPA
Speaker:
Bradford Dickerson (USA)
Moderator:
Corey McMillan (USA)
11:05 AM - 11:30 AM
Digital Metrics of Connected Speech
Speaker:
Jet Vonk (USA)
Moderator:
Corey McMillan (USA)
11:30 AM - 12:00 PM
Informatic Approaches to Big Data
Speaker:
Adam Staffaroni (USA)
Moderator:
Corey McMillan (USA)
12:00 PM - 1:00 PM
Salon IJKL Foyer
Lunch (Pre-Conference Workshop Registrants ONLY)
1:00 PM - 1:15 PM
Salon H
Opening Ceremony
Speakers:
David Irwin (USA), Manuela Neumann (Germany) & Olivier Piguet (University of Sydney)
1:15 PM - 1:30 PM
Salon H
A Historic Neuropathological Perspective of FTD
Speaker:
Virginia Lee
1:30 PM - 1:45 PM
Salon H
Presidential Lecture
Speaker:
Olivier Piguet (University of Sydney)
1:45 PM - 3:15 PM
Salon H
Plenary Session 1 - Update on Clinical Syndromes
Moderators:
Sterre de Boer (Alzheimercentrum Amsterdam) & Chiadi Onyike (USA)
1:45 PM - 2:15 PM
Right Temporal Variant FTD
Speaker:
Hulya Ulugut (USA)
2:15 PM - 2:45 PM
Lateralized Atrophy and Emotions in FTD
Speaker:
Virginia Sturm (USA)
2:45 PM - 3:15 PM
Redefining the ALS-FTD Spectrum: Biological & Clinical Considerations
Speaker:
Michael Strong (Canada)
3:15 PM - 3:45 PM
Franklin Hall B
Coffee Break / Visit Exhibits
3:45 PM - 5:15 PM
Salon H
Abstracts Session 1.1 - Behaviour / Cognition / Language
Moderators:
Jessica Hazelton (The University of Sydney) & Yolande Pijnenburg (The Netherlands)
3:45 PM - 4:00 PM
Automated Speech Analysis Identifies Clinical, Anatomical, and Pathological Variants of Primary Progressive Aphasia (#1001)
Speaker:
Jet Vonk (University of California, San Francisco)
4:00 PM - 4:15 PM
Predicting Amyloid Status in Primary Progressive Aphasia Using Explainable Artificial Intelligence (#1002)
Speaker:
Neguine Rezaii (Harvard Medical School)
4:15 PM - 4:30 PM
Clinically Validated Population Based Real World Data Reveal the Long Prodromal Phase and Societal Impact of Frontotemporal Dementia (#1003)
Speaker:
Eino Solje (University of Eastern Finland)
4:30 PM - 4:45 PM
The Causes of Prevalence Differences by Sex in Sporadic Behavioural Variant Frontotemporal Dementia (#1004)
Speaker:
Nol Swaddiwudhipong (University of Cambridge)
4:45 PM - 5:00 PM
Social Cognition Measures Support Differential Diagnosis of BvFTD, Psychiatric Disorders, and Alzheimer’s Disease (#1005)
Speaker:
Jan Van den Stock (KU Leuven)
5:00 PM - 5:03 PM
First Mexican Cohort of Frontotemporal Dementia at a Tertiary Cognitive Neurology Clinic (#1006)
Speaker:
Ramiro Ruíz-García (Instituto Nacional de Neurología y Neurocirugía "Manuel Velasco Suárez")
Cognitive and Neuropsychiatric Profiles in Left-Predominant svPPA and FTD with Right Anterior Temporal Lobe Predominance: Verbal-Semantic and Behavioral Differences in a Korean Cohort (#1009)
Moderators:
Edward Lee (University of Pennsylvania) & Soljee Yoon (University of California, San Francisco)
3:45 PM - 4:00 PM
Agentic Generative Artificial Intelligence Architecture for Classification of Pathology-Confirmed Primary Progressive Aphasia Variants (#1011)
Speaker:
Chiara Gallingani (University of Modena and Reggio Emilia)
4:00 PM - 4:15 PM
ANXA11 as Additional Pathological Marker for Tdp-43 Classification: A Post-Mortem Case Series of Rare Genetic, Mixed and Unclassifiable TDP-43 Pathologies (#1012)
Speaker:
Ana Rajicic (Erasmus University Medical Center)
4:15 PM - 4:30 PM
Discovery of a Novel and Specific Co-Aggregate Of pTDP-43 in svPPA (#1013)
Speaker:
Sevinc Jakab (Department of Neurology, Edward and Pearl Fein Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA)
4:30 PM - 4:45 PM
Superficial PPARG-Expressing Excitatory Neurons Are Selectively Vulnerable in the Medial Orbitofrontal Cortex of Behavioral Variant Frontotemporal Dementia (#1014)
Speaker:
Edward Lee (University of Pennsylvania)
4:45 PM - 5:00 PM
Spatial Transcriptomics Reveals Mechanisms of Hemispheric Asymmetry in TDP-C Frontotemporal Degeneration (#1015)
Speaker:
Brian Druciak (Northwestern University)
5:00 PM - 5:03 PM
Modeling the Selective Predilection of TDP-C Through Normal Annexin A11 Distribution (#1016)
Speaker:
Allegra Kawles (Northwestern University Feinberg School of Medicine)
Sustained Slowing of Cognitive-Linguistic Decline Following Long-Term Booster Neuromodulation in Logopenic Primary Progressive Aphasia: A 3-Year Case Study (#1032)
Speaker:
Kyrana Tsapkini (Johns Hopkins School of Medicine Faculty)
Beyond Apathy: Impaired Inhibitory Control as a Neurocognitive Explanation for the Apathy-Disinhibition Paradox (#1033)
Speaker:
Jordan Sibley (FRONTIER Frontotemporal Dementia Research Clinic)
Elevation of Cerebrospinal Fluid of Interferon-Stimulated Gene 15 (ISG15) is a Distinct Feature of FTLD-TDP Type C (#1038)
Speaker:
Peter A. Ljubenkov (University of California, San Francisco, Weill Institute for Neurosciences, Edward and Pearl Fein Memory and Aging Center)
Normative Data for the MoCA - Language (MoCA-L): Normative Data for the Moca - Language (Moca-L): Expanding Cognitive Screening to Language Deficits in Neurocognitive Disorders (#1056)
Speaker:
Robert Laforce (CHU de Québec-Université Laval)
Anterior Insula as a Disrupted Gating Hub: Altered Directional Communication Among Salience, Default Mode, and Frontoparietal Networks Impairs Social Inference in BvFTD (#1060)
Speaker:
Yu Chen (University of California, San Francisco)
Utility of a Machine Learning–Based Addenbrooke’s Cognitive Examination-III Subtyping Tool for Primary Progressive Aphasia and Alzheimer’s Disease (#1065)
Automated Metrics Reveal Differential Connected Speech Disruptions In nfvPPA and bvFTD (#1069)
Speaker:
Florentina Morello-Garcia (Edward and Pearl Fein Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA)
Acoustic Speech Metrics Derived From Repetition for Differential Diagnosis of Primary Progressive Aphasia Variants in Spanish: Effects of Task Type and Word Structure (#1083)
Speaker:
Miguel Santos-Santos (Sant Pau Memory Unit, IR Sant Pau, Hospital de la Santa Creu i Sant Pau)
A Deep-Learning Model of Structural Brain Aging Is Sensitive to Cognitive Impairment and Underlying Pathology in Behavioral and Dysexecutive Dementia Syndromes (#1092)
Speaker:
Jeff Phillips (University of Pennsylvania)
The Added Diagnostic Value of Social Cognition in Distinguishing Behavioural Variant Frontotemporal Dementia from Primary Psychiatric Disorders (#1098)
Disease Progression and Associated Atrophy in Primary Progressive Apraxia of Speech (#1100)
Speaker:
Syedah Khadeeja Shah (Brigham and Womewn's Hospital)
Navigating the Landscape of ANXA11 Proteinopathies (#1101)
Speaker:
Nikhil Ghayal (Mayo Clinic Florida)
The Famous Faces Maugeri Evaluation (FAME): Development of a New Ecologic Tool for Famous‑Face Recognition Aimed at Detecting the Right‑Temporal Variant FTD (#1102)
Speaker:
Maxime Montembeault (Douglas Research Centre & Department of Psychiatry, McGill University, Montreal, Canada)
The Influence of Clinical Features and Alzheimer’s Disease Biomarkers on the Diagnostic Trajectory of Suspected 4R-Tauopathies (#1103)
Distinct Patterns of Social Semantic Processing in Alzheimer’s Disease and Frontotemporal Lobar Degeneration: Evidence From the Dynamic Actions Semantic Congruency Task (#1106)
Speaker:
Deissy Milena Garcia García (Hospital Universitario Fundación Santa Fe, Hospital Universitario San Ignacio)
Unclassifiable Primary Progressive Aphasia: Evidence From a Pathology-Confirmed Cohort (#1114)
Speaker:
Florentina Morello-Garcia (Edward and Pearl Fein Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA)
Moderators:
Emily Feneberg (Department of Neurology, Technical University of Munich (TUM), School of Medicine and Health, TUM University Hospital, Ismaninger Straße 22, 81675 Munich, Germany) & Elise Marsan (National Institutes of Health, National Institute on Aging)
8:30 AM - 9:00 AM
Mapping the Exposome and Biomarker Signatures of Frontotemporal Dementia Across Latin America
Speaker:
Agustin Ibañez (Chile)
9:00 AM - 9:30 AM
RNA Dysregulation and Cryptic Splicing in TDP-43 Proteinopathy as Biomarker
Speaker:
Pietro Fratta (UK)
9:30 AM - 9:45 AM
Phenoconversion Prediction in Genetic FTD Using Machine Learning Models on Structural and Diffusion MRI Data (#2001)
Speaker:
Tine Swartenbroekx (Erasmus Medical Center Rotterdam)
9:45 AM - 10:00 AM
Interpretable MRI-Based Deep Learning for Classification of Alzheimer’s Disease and Behavioural Variant Frontotemporal Dementia in a Real-World Multicenter Cohort (#2002)
Speaker:
Francesca Orlandi (Ospedale San Raffaele)
10:00 AM - 10:30 AM
Franklin Hall B
Coffee Break / Visit Exhibits
10:30 AM - 12:00 PM
Salon H
Abstracts Session 2 - Biomarkers / Imaging
Moderators:
Indira Garcia Cordero (Cognitive Neuroscience Center, Universidad de San Andrés, Victoria, Buenos Aires, 1644, Argentina) & Howie Rosen (USA)
10:30 AM - 10:45 AM
Multi-Platform Cerebrospinal Fluid Proteomics Identifies and Validates MMP10 as a Diagnostic Biomarker for Pick’s Disease (#2003)
Speaker:
Rowan Saloner (University of California, San Francisco)
10:45 AM - 11:00 AM
Multiplex Blood-Based Proteomic Profiling Distinguishes Clinical Syndromes and Reveals Immune Pathways Associated With Neurodegeneration and Survival in Frontotemporal Lobar Degeneration (#2004)
Speaker:
Meira van Schaik (University of Cambridge)
11:00 AM - 11:15 AM
Large-Scale Proteomics Identifies Blood-Based Markers of Presymptomatic Disease in Familial Frontotemporal Lobar Degeneration (#2005)
Speaker:
Connor Dietz (UCSF, Edward and Pearl Fein Memory and Aging Center/UBC, Department of Medicine (Neurology))
11:15 AM - 11:30 AM
Digital Word Property Markers for Detecting Semantic Variant Primary Progressive Aphasia in Spanish-Speaking Latinos (#2006)
Speaker:
Ivan Caro (Cognitive Neuroscience Center, Department of Life and Behavioral Sciences, Universidad de San Andrés, Buenos Aires, Argentina; National Scientific and Technical Research Council (CONICET), Buenos Aire)
11:30 AM - 11:45 AM
FTLD-TDP and FTLD-tau Show Distinct Spatiotemporal Neuroimaging Signatures in Vivo (#2007)
Serum and CSF NULISA(tm) Biomarker Signatures and Clinical Associations in Behavioral-Variant Frontotemporal Dementia (#2012)
Speaker:
Cem Doğdu (German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; Department of Old Age Psychiatry and Cognitive Disorders, University Hospital Bonn, University of Bonn, Bonn, Germany)
Phase 1B/2A Biomarker Readout: Inhibition of Progranulin Binding to Sortilin With VES001 Normalizes Progranulin Levels and Engages Lysosomal and Synaptic Pathways in GRN Mutation Carriers (#2015)
Speaker:
Nina Schultz (Vesper Bio)
New Diagnosis Office Hours: An Introduction to Support and Resources after an FTD Diagnosis (#2016)
Blood-Based Synaptic Biomarkers in Frontotemporal Dementia: Insights from the BioMarker Initiative for Mental and Neurodegenerative Disorders (BIOMIND) Cohort (#2019)
Speaker:
Julia Peris-Subiza (Sant Pau Memory Unit, IR SANT PAU, Hospital de la Santa Creu i Sant Pau, Barcelona, 08025, Spain; Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Madrid, Spain)
White Matter Profiling in Semantic Variants of Frontotemporal Dementia and Primary Progressive Aphasia: Associations With Cortical Atrophy and Clinical Features (#2028)
Speaker:
Chiara Gallingani (University of Modena and Reggio Emilia)
Comparative Proteomics of CSF, Brain, and Spinal Cord Tissue in TDP-43 Compared with Non-TDP-43 Diseases (#2037)
Speaker:
Emily Feneberg (Department of Neurology, Technical University of Munich (TUM), School of Medicine and Health, TUM University Hospital, Ismaninger Straße 22, 81675 Munich, Germany)
Biological Sex Influences Clinical Phenotype Within a Global Cohort of AD and FTD Spectrum Disorders (#2043)
Speaker:
Zachary Miller (The Edward and Pearl Fein Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco)
In Their Words: Children and Young Adults Navigating Familial Neurodegenerative Disease (#2049)
Speaker:
Rowan Heffelfinger (University of California San Francisco)
Mapping Motivational Disturbances to Limbic Striatal Subdivisions Across the Frontotemporal Dementia Spectrum: A Connectivity-Based Shape Analysis (#2050)
Speaker:
Angelo Arimboyutan Bumanglag (The University of Sydney)
Iron-Rich Gliosis Detected by Ultra-High Resolution 7T T2*W Ex Vivo MRI Differ Between Pathological Subtypes of Behavioral Variant Frontotemporal Dementia (#2052)
Speaker:
Sheina Emrani (University of Pennsylvania)
Digital Phenotyping of Apathy and Anhedonia In bvFTD and AD in Ecological Settings (#2054)
Speaker:
Julie Behenska (Sorbonne University, Institut du Cerveau - Paris Brain Institute - ICM, FrontLAB, Inserm, CNRS, AP-HP, Pitié Salpêtrière Hospital / Brain and Mind Centre, The University of Sydney / School of Psycholo)
Generalizable Speech Biomarkers for Behavioral Variant Frontotemporal Dementia and Alzheimer’s Disease Across Socioculturally Diverse Latino Populations (#2109)
Speaker:
Franco Ferrante (Cognitive Neuroscience Center, San Andres University)
Supporting Unpaid Carers in Frontotemporal Lobar Degeneration: A Scoping Review of Behavioural Symptom Interventions (#2066)
Speaker:
Ana Paula Trucco (University of East Anglia)
TRACK-FTD: Three-Dimensional Face-Tracking as an Objective Digital Marker of Empathy in FTD (#2079)
Speaker:
Cem Doğdu (German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; Department of Old Age Psychiatry and Cognitive Disorders, University Hospital Bonn, University of Bonn, Bonn, Germany)
Diffusivity Along the Perivascular Space (DTI - ALPS) Impairment in Grn-Mutated Frontotemporal Dementia: A Distinct Pathophysiological Signature (#2087)
Speaker:
Francesca Orlandi (Ospedale San Raffaele)
Story Retelling Discourse Markers Distinguish Semantic Variant Primary Progressive Aphasia in Spanish-Speaking Latinos (#2091)
Speaker:
Florentina Morello-Garcia (Edward and Pearl Fein Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA)
Moderators:
Peter A. Ljubenkov (University of California, San Francisco, Weill Institute for Neurosciences, Edward and Pearl Fein Memory and Aging Center) & Rik Vandenberghe (University Hospitals Leuven)
8:30 AM - 9:00 AM
Digital Health Assessments in FTLD
Speaker:
Adam Staffaroni (USA)
9:00 AM - 9:30 AM
Update on Tau Targeting Trials in PSP/CBS
Speaker:
Günter Höglinger (Germany)
9:30 AM - 10:00 AM
From Care to Clinical Trials: Centering Individuals and Families in FTD Research
Speaker:
Lauren Massimo (University of Pennsylvania)
10:00 AM - 10:30 AM
Franklin Hall B
Coffee Break / Visit Exhibits
10:30 AM - 12:00 PM
Salon I-L
Abstracts Session 3.1 - Genetics
Moderators:
Nadia Dehghani (University of Pennsylvania) & Cyril Pottier (USA)
10:30 AM - 10:45 AM
A Large-Scale GWAS of Clinical Frontotemporal Dementia Identifies Known and Emerging Associated Loci (#3001)
Speaker:
Lianne Reus (Amsterdam UMC | University College London)
10:45 AM - 11:00 AM
Genetic Predisposition for Developmental Dyslexia in Semantic Variant Primary Progressive Aphasia (#3002)
Speaker:
Sterre de Boer (Alzheimercentrum Amsterdam)
11:00 AM - 11:15 AM
Chinese National Multicenter Genomic Study on Frontotemporal Dementia: CHIFGENS (#3003)
Speaker:
Liyong Wu (Xuanwu Hospital, Capital Medical University, Beijing, China)
11:15 AM - 11:30 AM
Genome Wide Association Studies Characterize Risk Loci Underlying CBD and PiD Biology (#3004)
Speaker:
Nicole Tamvaka (Mayo Clinic)
11:30 AM - 11:45 AM
A Single Nucleus Meta-Atlas of FTLD-TDP and ALS Reveals Cell Type Specific Cryptic Splicing and Alternative Polyadenylation (#3005)
Speaker:
Alice Maria Giani (Icahn School of Medicine at Mount Sinai)
11:45 AM - 11:48 AM
Frontotemporal Lobar Degeneration associated with TBK1 Variants: Clinical and Neuropathological Features (#3006)
Speaker:
Manizhe Eslami-Amirabadi (University of Washington)
Ropinirole, an Orally Available Clinical Candidate for Sporadic FTLD: Subtype-Independent Neuronal Rescue via Lysosome/Autophagy Modulation in Patient-Derived IPSC Models (#3021)
Speaker:
Hiroshi Kokubu (K Pharma, Inc.)
Reading the Gene in the Eye: Clinical Discrimination and Metacognition in Genetic FTD (#3022)
Combined Transcranial Magnetic Stimulation and Transcranial Electrical Stimulation Associated With Language Therapy in Primary Progressive Aphasia: Protocol of a Double-Blind, Parallel, and Randomized Clinical Trial (#3034)
Speaker:
Lucia Fernandez-Romero (The University of Texas at Austin)
Speech-Language Interventions in Primary Progressive Aphasia: A Continuum of Restitutive, Compensatory, Partner-Focused, and Psychosocial Approaches (#3041)
Speaker:
Maya Henry (University of Texas at Austin)
In Vitro Experimental Validation Pipeline for Discovering Small‑Molecule Inhibitors of TDP‑43 Aggregation (#3067)
Speaker:
Lea El Hajjar (Institut du cerveau)
Investigating Apathy Across Disease Stages and Genetic Groups in Frontotemporal Dementia (FTD) Within the GENetic FTD Initiative (GENFI) Cohort (#3068)
Speaker:
Sophie Farley (University College London)
The Value of Multivariate Clinical Patterns Using Representational Similarity Analysis in Differentiating Frontotemporal Dementia From Primary Psychiatric Disorders (#3077)
Speaker:
Sterre de Boer (Alzheimercentrum Amsterdam)
Rare Genetic Variants Influence Serum Neurofilament Light Chain Levels in Genetic Frontotemporal Dementia: A GENFI Study (#3078)
Speaker:
Saira Mirza (Sunnybrook Health Sciences Center)
Annexin A11 Co-Localizes with Synaptic and Cytoskeletal Protein in Healthy Neurons and Co-Aggregates with Synaptic and Cytoskeletal Proteins in FTLD-TDP Post-Mortem Brains (#3086)
Speaker:
Katherine Dorfman (University of Pennsylvania)
Long-term Overexpression of Carboxy-Terminal Blocked Progranulin Corrects Behavioral, Lysosomal, and Microglial Phenotypes up to One Year Post Injection (#3089)
Speaker:
Vivianna DeNittis (University of Alabama at Birmingham)
Hiryama Disease Presentation with FrontHiryama Disease Presentation With Frontal Signs in a Patient With TARDBP Mutation and a Strong Family History of FTD (#3092)
Speaker:
Alicia Parker (Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases)
Neuropsychiatric Symptoms Map Accelerated Whole-Brain and Circuit Specific Clocks in Frontotemporal Dementia and Alzheimer’s Disease (#3093)
Speaker:
Jessica Hazelton (The University of Sydney)
Gene Expression Signatures in Genetic and Sporadic Frontotemporal Dementia: Insight Into Autophagy, Inflammation, and Oxidative Stress (#3094)
Speaker:
Chiara Fenoglio (IRCCS Ca' Granda Foundation Ospedale Maggiore Policlinico, University of Milan)
Conditional Wild-Type Human TDP-43 Transgenic Mouse Model Recapitulates Key Pathological and Behavioral Features of FTD (#3095)
Speaker:
Emmanuel Adebanjo (Northwestern University, Feinberg School of Medicine)
Aβ42 Induces Selective Degeneration in Hippocampal Cells of Aged Monkeys (#3096)
Speaker:
Jiawei Zhang (Department of neurology,The Second Clinical Medical College , Jinan University (Shenzhen People's Hospital), Shenzhen 518020,China. The First Affiliated Hospital, Jinan University, Guangzhou)
ZNF746/PARIS as a Potential Pathological Hub Extending from Parkinson’s Disease to Frontotemporal Dementia (#3097)
CSF Proteome Signatures in FTD Are Dependent on the Presence of AD Copathology (#3098)
Speaker:
Frederika Malichova (Amsterdam UMC)
Predictors of Word-Level Treatment Response in Primary Progressive Aphasia: A Post-Hoc Analysis of a Randomized Controlled Trial of Transcranial Magnetic Stimulation (#3099)
Speaker:
Jordi A Matias-Guiu (Hospital Clinico San Carlos)
A "Double-Hit" Model of Proteostasis Collapse? Linking OPTN c.493C>T and TMEM106B Processing to Pure FTD-TDP Type A (#3101)
Speaker:
Roberta Giannelli (Vrije Universiteit Amsterdam)
Clinical and Neuroanatomical Characterization of a Colombian Patient With Semantic Variant Primary Progressive Aphasia Carrying a TARDBP p.i383v Variant (#3102)
Building Opportunities for Collaboration Between Anthropology and the Clinical Neurosciences to Improve Frontotemporal Dementia Diagnosis and Care (#3103)
Speaker:
Juliana Friend (University of California, San Francisco)
Speaker:
Paula Polanco Miquel (VIB Center for Molecular Neurology)
5:00 PM - 7:00 PM
Salon I-L
ISTAART PIA Workshop: Integrating Diversity into Frontotemporal Dementia Research: From Biological Insight to Equitable Clinical Practice (Separate Registration Required)
Sunday, October 11, 2026
8:30 AM - 10:30 AM
Salon H
Plenary Session 6 - HOT Topics
Moderators:
Maura Malpetti (University of Cambridge) & Jonathan Rohrer (UK)
8:30 AM - 8:45 AM
First-in-Human Evaluation of [¹⁸F]ACI-19626, a Novel TDP-43 PET Tracer (#4006)
Speaker:
Tamara Seredenina (AC Immune)
8:45 AM - 9:00 AM
Initial Biomarker Results from A Phase 2a Clinical Trial of Neflamapimod in Patients with Nonfluent Variant Primary Progressive Aphasia (#4007)
Speaker:
John Alam (CervoMed Inc.)
9:00 AM - 9:15 AM
Biomarkers, Efficacy, and Safety of PR006, an Investigational AAV9 Gene-Therapy in Frontotemporal Dementia Patients with GRN Mutations (#4002)
Speaker:
Travis Lewis (Eli Lilly and Company)
9:15 AM - 9:30 AM
ASPIRE-FTD Study Update: A Phase 1/2 Study to Evaluate AVB-101 in FTD with GRN Mutations (#4004)
Phase 1B/2A Data: Inhibition of Progranulin Binding to Sortilin With VES001 in Grn Mutation Carriers Is Well-Tolerated and Normalizes Plasma and CSF Progranulin (#4005)
Speaker:
Nina Schultz (Vesper Bio)
9:45 AM - 10:00 AM
Standardizing Excellence: Training Clinical Research Coordinators for FTD Trials (#4001)
Speaker:
Shana Dodge (The Association for Frontotemporal Degeneration)